Nucleolar RNA-binding
Gene co-expression module in Enterocytes
| Category | RNA processing & translation |
|---|---|
| Genes | 11 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 9 of 11 genes have a known function matching the annotation |
Why this annotation
PTMA, NPM1, NCL, the HNRNPA family, PABPC1, HMGN2 and HMGB1 form a classic program of proliferative, ribosome-biogenesis-high progenitor cells. HSP90 chaperones accompany it. The genes are RNA-binding and nucleolar, with high growth activity.
Genes
HMGB1, HMGN2, HNRNPA1, HNRNPA2B1, HNRNPA3, HSP90AA1, HSP90AB1, NCL, NPM1, PABPC1, PTMA
Most correlated modules
- Redox Detoxification · correlation 0.84
- Translation Elongation · correlation 0.81
- Mitochondrial Chaperonin · correlation 0.73
- Transit-amplifying progenitor · correlation 0.70
- Respiratory Chain OXPHOS · correlation 0.68
- Crypt antimicrobial progenitor · correlation 0.63
- Abundant Transcript Baseline · correlation 0.62
- IFN-gamma immunoproteasome · correlation 0.62
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.