MGST1 — Microsomal glutathione S-transferase 1
MGST1 belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
MGST1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Enterocytes | Mitochondrial Chaperonin Mitochondrial & OxPhos | HINT1, HSPD1, HSPE1, NDUFB1, OST4, TMA7 | View in SCUBA |
| Goblet cells | Glutathione Detoxification Stress | EIF3K, GSTP1, HINT1, HMGA1, MGST3, SLIRP, SNRPD2, TST +1 more | View in SCUBA |
| Hematopoietic progenitor cells | Granulocyte Commitment Granulocyte development | C16orf74, C1QTNF4, CEACAM4, CEBPA, CLEC11A, CPVL, CSF3R, IGFBP2 +6 more | |
| Macrophages | Inflammatory Monocyte Activation Inflammatory | ANPEP, AQP9, CD300E, CD82, CLEC5A, CXXC5, DDX60L, DHRS9 +25 more | View in SCUBA |
| Monocytes | Inflammatory Monocyte Activation Inflammatory | ANG, ANXA2, CD99, IGFBP7, PLAAT3, RNASE2, S100A10, ST14 | View in SCUBA |
| Neutrophils | Translational Housekeeping Housekeeping | COX4I1, EEF1A1, EEF1B2, GSTP1, NPM1, RACK1, UBA52, YBX1 |
About the gene
| Synonyms | GST12, MGST-I, PMAN |
|---|---|
| Chromosome | 12: 16347142-16609259 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Enzymes, Metabolic proteins, Predicted membrane proteins |
| Molecular function | Transferase |
Function
Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.