Long-gene nuclear transcripts
Gene co-expression module in Enterocytes
| Category | Technical artifact |
|---|---|
| Genes | 8 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 7 of 8 genes have a known function matching the annotation |
Why this annotation
Nearly all members are very long, intron-rich genes: SLC2A13, TCF7L2, MYO1E, EPS8, CEMIP2, ANKRD12 and GCC2. There is no coherent shared pathway, and detection is high and uniform (91%). This pattern typically reflects intronic or nascent pre-mRNA capture (nuclear transcript fraction), which co-varies across cells for technical reasons. MYO1E and EPS8 are microvillar actin regulators and TCF7L2 is a Wnt effector, so a brush-border component cannot be excluded. The long-gene signature (also partially present in neighbor M22) best explains the co-expression.
Genes
ANKRD12, CEMIP2, EPS8, ETNK1, GCC2, MYO1E, SLC2A13, TCF7L2
Most correlated modules
- STAT3/JNK signaling · correlation 0.84
- KLF4 Terminal Differentiation · correlation 0.81
- EGFR wound response · correlation 0.79
- Basal adhesion remodeling · correlation 0.77
- Long-gene nuclear transcripts · correlation 0.76
- NF-kB epithelial activation · correlation 0.75
- Inflammatory hypoxic response · correlation 0.74
- JUN stress response · correlation 0.70
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.