EGFR wound response
Gene co-expression module in Enterocytes
| Category | Epithelial development |
|---|---|
| Genes | 7 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 6 of 7 genes have a known function matching the annotation |
Why this annotation
KLF6, ERRFI1, GPRC5A, CLDN4 and STOM mark an EGFR/early-response injury and restitution state of colonic epithelium. CLDN4 and GPRC5A are induced in regenerating or inflamed epithelium, and ERRFI1 is the EGFR feedback inhibitor. SNX9 is involved in endocytosis. DDX60L links the module to the neighboring IFN program.
Genes
CLDN4, DDX60L, ERRFI1, GPRC5A, KLF6, SNX9, STOM
Most correlated modules
- Inflammatory hypoxic response · correlation 0.91
- NF-kB epithelial activation · correlation 0.86
- Basal adhesion remodeling · correlation 0.81
- JUN stress response · correlation 0.81
- TNF receptor signaling · correlation 0.79
- Stress-responsive transcription · correlation 0.79
- Long-gene nuclear transcripts · correlation 0.79
- STAT3/JNK signaling · correlation 0.78
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.