JUN stress response
Gene co-expression module in Enterocytes
| Category | Stress |
|---|---|
| Genes | 8 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 4 of 8 genes have a known function matching the annotation |
Why this annotation
JUN and FOXO3 are stress-response transcription factors. LAMA3 and LAMB3 are laminin-332 chains. Replication histones (H1-2, H2AC6) and ZNF292 are also present. The JUN hub with laminin-332 suggests a wound or stress response, possibly with a dissociation-stress contribution given its neighbors. Laminin-332 induction in injured or migrating epithelium supports a restitution-like state.
Genes
FOXO3, H1-2, H2AC6, JUN, LAMA3, LAMB3, PTPRB, ZNF292
Most correlated modules
- TNF receptor signaling · correlation 0.91
- Brush border lipid handling · correlation 0.86
- Stress-responsive transcription · correlation 0.82
- Junctional Hippo/TGF-beta signaling · correlation 0.81
- EGFR wound response · correlation 0.81
- Inflammatory hypoxic response · correlation 0.79
- Endocytic nutrient uptake · correlation 0.76
- KLF4 Terminal Differentiation · correlation 0.76
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.