MYO1E — Myosin IE
MYO1E belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
MYO1E's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | Dark-zone GC B-cell B cell maturation | BRWD1, CCDC144A, CCDC88A, CD38, FGD6, LPP, MYBL1, RAPGEF5 +2 more | View in SCUBA |
| Endothelial | Inflammatory Kinase Signaling Inflammation | ANKRD28, CBL, CDC123, CNN2, DGKH, EOGT, FADS3, FYN +7 more | View in SCUBA |
| Enterocytes | Long-gene nuclear transcripts Technical artifact | ANKRD12, CEMIP2, EPS8, ETNK1, GCC2, SLC2A13, TCF7L2 | View in SCUBA |
| Gamma-delta T cells | Tissue Resident CD103+ Tissue residence | ADRB1, BCAS4, BLMH, CCNJL, CD160, CD96, CLIC5, CLNK +28 more | |
| Macrophages | Alternative Activation Lipid Lipid metabolism | ACSL1, ADCY3, AGFG1, ARHGEF10L, ARID5B, ATP2B4, BCL6, CCL13 +24 more | View in SCUBA |
| Natural Killer cells | Tissue-Resident NK Gut residency | ADRB1, CAMK4, GPR34, GPR55, ITGAE, LRRC25, NCR2, S100A13 +2 more | View in SCUBA |
About the gene
| Synonyms | HuncM-IC, MGC104638, MYO1C |
|---|---|
| Chromosome | 15: 59132434-59372871 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Predicted intracellular proteins |
| Molecular function | Actin-binding, Calmodulin-binding, Motor protein, Myosin |
Function
Actin-based motor molecule with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails bind to membranous compartments, which are then moved relative to actin filaments. Binds to membranes containing anionic phospholipids via its tail domain. Involved in clathrin-mediated endocytosis and intracellular movement of clathrin-coated vesicles. Required for normal morphology of the glomerular basement membrane, normal development of foot processes by kidney podocytes and normal kidney function. In dendritic cells, may control the movement of class II-containing cytoplasmic vesicles along the actin cytoskeleton by connecting them with the actin network via ARL14EP and ARL14.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.