Enterocyte lipid metabolism
Gene co-expression module in Enterocytes
| Category | Lipid metabolism |
|---|---|
| Genes | 12 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 9 of 12 genes have a known function matching the annotation |
Why this annotation
Mature enterocyte metabolic program. Lipid droplet and fatty acid handling genes (PLIN2, CYP4F2, PHYH) co-occur with gluconeogenesis (PCK1), zinc uptake (SLC39A4), the enterocyte marker MS4A10, and redox genes (GPX4, DHDH). The profile is typical of small-intestine-like or ileal/colonic absorptive enterocytes. Neighbors M79, M65 and M38 are all brush-border absorptive programs, which supports a differentiated enterocyte metabolic state.
Genes
CYP4F2, DHDH, GPX4, MS4A10, OCIAD2, PCK1, PHYH, PLIN2, SAT2, SLC39A4, TMBIM6, TMED4
Most correlated modules
- Villus-tip enterocyte transport · correlation 0.94
- Amino acid absorption · correlation 0.93
- Brush-border Nutrient Uptake · correlation 0.89
- Brush-border nutrient uptake · correlation 0.89
- Microvillus actin cytoskeleton · correlation 0.89
- Colonocyte Solute Transport · correlation 0.86
- Chylomicron lipid absorption · correlation 0.86
- Crypt-top colonocyte · correlation 0.85
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.