Chylomicron lipid absorption
Gene co-expression module in Enterocytes
| Category | Lipid metabolism |
|---|---|
| Genes | 12 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 11 of 12 genes have a known function matching the annotation |
Why this annotation
The hub genes MTTP, DGAT1, MOGAT2 and FABP2 form the enterocyte dietary-fat pathway: monoacylglycerol re-esterification, triglyceride synthesis and chylomicron assembly. ALDOB marks fructose metabolism. MYO1A, ANPEP, ENPEP and NHERF1 are brush-border components, and CNDP2 is a dipeptidase. Together these describe a mature absorptive enterocyte program led by lipid handling. In the colon this may reflect small-intestine-like or proximal absorptive cells. Uniform, high expression is consistent with a true enterocyte program rather than contamination. Its neighbor M99 shares the fatty-acid theme (ACSL5, ACOX1).
Genes
ACO2, ALDOB, ANPEP, CNDP2, DGAT1, ENPEP, FABP2, MOGAT2, MTTP, MYO1A, NHERF1, SMIM24
Most correlated modules
- Brush-border nutrient uptake · correlation 0.93
- Amino acid absorption · correlation 0.92
- Villus-tip enterocyte transport · correlation 0.91
- Lipid/bile acid uptake · correlation 0.89
- Gluconeogenesis/fructose metabolism · correlation 0.88
- Amino acid absorption · correlation 0.87
- Enterocyte fatty-acid catabolism · correlation 0.87
- Colonocyte Solute Transport · correlation 0.86
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.