Ribosome Biogenesis
Gene co-expression module in Fibroblasts
| Category | Housekeeping |
|---|---|
| Genes | 10 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 8 of 10 genes have a known function matching the annotation |
Why this annotation
Hub genes include EEF1B2 (elongation factor 1-beta, translation), EIF3K and EIF3G (eukaryotic initiation factor 3 subunits), BTF3 (basic transcription factor 3, also involved in translation), SLC25A6 (mitochondrial ADP/ATP translocase), SUMO2 (small ubiquitin-like modifier), SNRPD2 (spliceosomal snRNP), and ribosomal proteins RPL4, RPS10, RPL36AL. The module is core coherent. The combination of translation initiation factors (EIF3K, EIF3G), elongation factor (EEF1B2), ribosomal proteins, and BTF3 clearly indicates a translation/ribosome biogenesis housekeeping program. SUMO2 and SNRPD2 add RNA processing components. Neighbor context: directly neighbors M69, M29, M8 which are all ribosomal protein modules, confirming this is part of a broader translation housekeeping neighborhood.
Genes
BTF3, EEF1B2, EIF3G, EIF3K, RPL36AL, RPL4, RPS10, SLC25A6, SNRPD2, SUMO2
Most correlated modules
- General Housekeeping · correlation 0.95
- Mitochondrial OXPHOS · correlation 0.94
- WAVE-RAC1 Actin · correlation 0.93
- Translation Initiation · correlation 0.93
- ER-Golgi Trafficking · correlation 0.92
- Rho GTPase Cytoskeletal · correlation 0.90
- Mitochondrial OxPhos · correlation 0.88
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.