General Housekeeping
Gene co-expression module in Fibroblasts
| Category | Housekeeping |
|---|---|
| Genes | 13 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 11 of 13 genes have a known function matching the annotation |
Why this annotation
This core-coherence module contains genes involved in diverse housekeeping functions: SEC11A and SPCS2 (signal peptidase complex, co-translational processing), CLTA (clathrin light chain, endocytosis), SNX3 (sorting nexin, endosomal trafficking), ATP6V0E1 (vacuolar ATPase, vesicular acidification), NEDD8 (neddylation/ubiquitin-like), PARK7 (DJ-1, redox sensor/chaperone), ERH (enhancer of rudimentary homolog, RNA processing), SNU13 (snRNP, splicing), SRSF9 (splicing factor), EDF1 (transcription elongation), TMEM14C (mitochondrial porphyrin transport), C19orf53. The module spans RNA processing, protein trafficking, and ubiquitin-like modification — classic housekeeping functions. Uniform expression across subsets and moderate disease association support a general cellular maintenance program.
Genes
ATP6V0E1, C19orf53, CLTA, EDF1, ERH, NEDD8, PARK7, SEC11A, SNU13, SNX3, SPCS2, SRSF9, TMEM14C
Most correlated modules
- ER Secretory Processing · correlation 0.97
- Cullin-RING Ubiquitin Ligase · correlation 0.97
- ER-Golgi Trafficking · correlation 0.96
- Rho GTPase Cytoskeletal · correlation 0.96
- Mitochondrial OXPHOS · correlation 0.96
- Ribosome Biogenesis · correlation 0.95
- WAVE-RAC1 Actin · correlation 0.95
- ER-Golgi Trafficking · correlation 0.94
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.