WAVE-RAC1 Actin
Gene co-expression module in Fibroblasts
| Category | Cytoskeletal |
|---|---|
| Genes | 10 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 4 of 10 genes have a known function matching the annotation |
Why this annotation
Top hub genes BRK1 and RAC1 are core components of the WAVE/WASP actin nucleation complex (BRK1 is a WAVE complex subunit; RAC1 activates WAVE). DYNLRB1 (dynein light chain, cytoskeletal motor), YWHAB (14-3-3 beta, RAC1 signaling scaffold). CHCHD2 is a mitochondrial inner membrane protein (MINOS complex). PPIA (cyclophilin A, chaperone/isomerase), SSR2 (ER translocon), MRFAP1 (chromatin-associated), C4orf3, C11orf58 are housekeeping. The dominant cytoskeletal signal (BRK1, RAC1, DYNLRB1) with WAVE complex identity is the clearest program. Core coherence. Neighbor to M42 (actin cytoskeleton module) supports cytoskeletal classification.
Genes
BRK1, C11orf58, C4orf3, CHCHD2, DYNLRB1, MRFAP1, PPIA, RAC1, SSR2, YWHAB
Most correlated modules
- ER-Golgi Trafficking · correlation 0.97
- General Housekeeping · correlation 0.95
- Proteasome & OxPhos · correlation 0.94
- Mitochondrial OXPHOS · correlation 0.94
- Mitochondrial OxPhos · correlation 0.94
- Cullin-RING Ubiquitin Ligase · correlation 0.93
- Ribosome Biogenesis · correlation 0.93
- ER Secretory Processing · correlation 0.92
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.