Rho GTPase Cytoskeletal
Gene co-expression module in Fibroblasts
| Category | Cytoskeletal |
|---|---|
| Genes | 11 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 6 of 11 genes have a known function matching the annotation |
Why this annotation
The top hub genes are RHOC and RHOA, both Rho GTPases central to actin cytoskeleton regulation and cell motility. Supporting genes include S100A11 (actin-binding, cytoskeletal), CLIC1 (chloride channel linked to cytoskeletal dynamics), RAB34 (vesicular trafficking/cytoskeletal), SRM (polyamine synthesis, cell growth), CYBA (NADPH oxidase subunit), LY6E, APRT, TMEM50A, and HSBP1. The module is upregulated in UC inflammation. The dominant theme is Rho GTPase-driven cytoskeletal regulation in fibroblasts, consistent with inflammatory activation and motility programs. RHOA and RHOC together strongly anchor this as a Rho GTPase/cytoskeletal module.
Genes
APRT, CLIC1, CYBA, HSBP1, LY6E, RAB34, RHOA, RHOC, S100A11, SRM, TMEM50A
Most correlated modules
- General Housekeeping · correlation 0.96
- ER Secretory Processing · correlation 0.95
- Cullin-RING Ubiquitin Ligase · correlation 0.93
- Proteasome Assembly · correlation 0.92
- Mitochondrial OXPHOS · correlation 0.92
- ER Protein Processing · correlation 0.92
- ER-Golgi Trafficking · correlation 0.92
- ER-Golgi Trafficking · correlation 0.91
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.