EEF1B2 — Eukaryotic translation elongation factor 1 beta 2

EEF1B2 belongs to a gene co-expression module in 16 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

EEF1B2's module in each cell type

Cell type	Module	Shares the module with
CD8⁺ T cells	Naive/Memory CD8 T cell maturation	C1orf162, CD48, CD55, GPR155, IL7R, MATK, MYBL1, NACA +3 more	View in SCUBA
Endothelial	Translation Elongation RNA processing & translation	CCNI, COMMD6, EEF1A1, EEF2, EIF3F, EIF3L, EIF4B, FBL +7 more	View in SCUBA
Enterocytes	Translation Elongation RNA processing & translation	ATP5F1E, ATP5MC2, BTF3, EEF1A1, EIF3E, NACA, NDUFC2, PFDN5 +5 more	View in SCUBA
Fibroblasts	Ribosome Biogenesis Housekeeping	BTF3, EIF3G, EIF3K, RPL36AL, RPL4, RPS10, SLC25A6, SNRPD2 +1 more	View in SCUBA
Gamma-delta T cells	Translation Initiation RNA processing & translation	BTF3, C12orf57, COMMD6, COX4I1, COX7C, EEF1D, EEF1G, EIF3E +18 more
Glial cells	RNA Translation Processing RNA processing & translation	CYCS, EEF1D, HNRNPA1, HNRNPH3, LDHA, NAP1L1, NPM1, PFDN5 +5 more	View in SCUBA
Goblet cells	mRNA Translation Initiation RNA processing & translation	EEF1A1, EIF3D, EIF3E, EIF3F, EIF3L, PABPC1, RACK1, SLC25A6 +2 more	View in SCUBA
Hematopoietic progenitor cells	Biosynthetic Housekeeping Housekeeping	BZW2, CHST12, CREG1, FBL, HNRNPA1, HSP90AB1, IMPDH2, LDHB +7 more
Innate lymphoid cells	Mitochondrial Housekeeping Mitochondrial & OxPhos	COX7A2, COX7B, EIF1AX, FTH1, HNRNPC, ID2, NAP1L1, POMP +8 more	View in SCUBA
Lymphatic endothelial	mRNA Translation Regulation RNA processing & translation	BTF3, BZW1, CLIC1, GAPDH, NPM1, SDCBP, YBX1, YWHAE	View in SCUBA
Macrophages	Mitochondrial OXPHOS Mitochondrial & OxPhos	APRT, ARPC3, ATP5F1E, ATP5MF, ATP5MG, BLOC1S1, BTF3, CLTB +28 more	View in SCUBA
Monocytes	Biosynthetic Metabolic Activation Housekeeping	AHCY, IMPDH2, NME1, NPM1, NUCKS1, PABPC4, PEBP1, PRDX4 +4 more	View in SCUBA
Mucosal-associated invariant T cell	Translation Elongation RNA processing & translation	BAX, BTF3, COX4I1, EEF1D, EIF3K, FAU, FTL, GPX4 +8 more
Natural Killer cells	Translation Elongation RNA processing & translation	BTF3, COMMD6, EEF1A1, EEF1D, EIF3E, NACA, NOP53, PFDN5 +3 more	View in SCUBA
Neutrophils	Translational Housekeeping Housekeeping	COX4I1, EEF1A1, GSTP1, MGST1, NPM1, RACK1, UBA52, YBX1
Smooth muscle cells	Ribonucleoprotein & translation RNA processing & translation	CRYAB, CYB5R3, HMGB1, HNRNPC, LAPTM4A, MAGED2, NACA, NCL +5 more	View in SCUBA

About the gene

Chromosome	2: 206159585-206162928
Predicted location	Intracellular
Essential gene	Yes
Protein class	Essential proteins, Plasma proteins, Predicted intracellular proteins
Molecular function	Elongation factor
Biological process	Protein biosynthesis

Function

Catalytic subunit of the guanine nucleotide exchange factor (GEF) (eEF1B subcomplex) of the eukaryotic elongation factor 1 complex (eEF1) (By similarity). Stimulates the exchange of GDP for GTP on elongation factor 1A (eEF1A), probably by displacing GDP from the nucleotide binding pocket in eEF1A (By similarity)

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.