Mitochondrial OxPhos
Gene co-expression module in Fibroblasts
| Category | Mitochondrial & OxPhos |
|---|---|
| Genes | 15 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 13 of 15 genes have a known function matching the annotation |
Why this annotation
Hub genes are predominantly mitochondrial respiratory chain subunits: COX6A1, COX6C (Complex IV), NDUFB10, NDUFB9, NDUFB7, NDUFB4, NDUFA8, NDUFA12 (Complex I), ATP5PF (Complex V/ATP synthase), VDAC2 (mitochondrial outer membrane voltage-dependent anion channel). GSTP1, PRDX2, MGST3 are glutathione-S-transferase/peroxiredoxin antioxidants that protect mitochondria from ROS. VPS29 (retromer complex) and NUCB2 are peripheral. Core coherence and uniform expression confirm a tight mitochondrial OxPhos program. Neighbor to M105 which also contains OxPhos genes, reinforcing the mitochondrial neighborhood.
Genes
ATP5PF, COX6A1, COX6C, GSTP1, MGST3, NDUFA12, NDUFA8, NDUFB10, NDUFB4, NDUFB7, NDUFB9, NUCB2, PRDX2, VDAC2, VPS29
Most correlated modules
- Mitochondrial Energy Metabolism · correlation 0.95
- Proteasome & OxPhos · correlation 0.95
- ER-Golgi Trafficking · correlation 0.95
- WAVE-RAC1 Actin · correlation 0.94
- Mitochondrial OXPHOS · correlation 0.92
- General Housekeeping · correlation 0.92
- ER-Golgi Trafficking · correlation 0.91
- Cullin-RING Ubiquitin Ligase · correlation 0.91
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.