ER-Golgi Trafficking
Gene co-expression module in Fibroblasts
| Category | Vesicular traficking |
|---|---|
| Genes | 15 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 10 of 15 genes have a known function matching the annotation |
Why this annotation
Hub genes ATP6AP2 (vacuolar ATPase/lysosomal), RAB2A (ER-Golgi vesicle trafficking), TMEM59 (lysosomal membrane), TMEM230 (vesicle trafficking), ARF1 (Golgi vesicle budding), SRP14/SRP9 (signal recognition particle for ER targeting), SELENOF (ER-resident selenoprotein), PTGES3 (ER-resident prostaglandin synthase) collectively define an ER-to-Golgi vesicular trafficking and ER protein targeting program. YWHAE (14-3-3 epsilon) and ANXA5 are peripheral. The module is uniformly expressed across fibroblast subsets, core coherence, consistent with a constitutive housekeeping vesicular trafficking program. Slight decrease in CD inflammation. Neighbor context: sits adjacent to OxPhos/metabolic modules, consistent with general cellular housekeeping.
Genes
ANXA5, ARF1, ATP6AP2, MORF4L1, MTDH, OCIAD1, PTGES3, RAB2A, SELENOF, SERBP1, SRP14, SRP9, TMEM230, TMEM59, YWHAE
Most correlated modules
- WAVE-RAC1 Actin · correlation 0.97
- General Housekeeping · correlation 0.96
- Proteasome & OxPhos · correlation 0.96
- ER-Golgi Trafficking · correlation 0.95
- Mitochondrial OxPhos · correlation 0.95
- ER Protein Folding · correlation 0.95
- Mitochondrial Energy Metabolism · correlation 0.94
- ER Secretory Processing · correlation 0.93
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.