Complement-producing Fibroblast
Gene co-expression module in Fibroblasts
| Category | Inflammatory |
|---|---|
| Genes | 17 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 8 of 17 genes have a known function matching the annotation |
Why this annotation
C3 (complement component 3) and TNFRSF1B (TNF receptor 2) indicate inflammatory signaling. PTGDS (prostaglandin D2 synthase) and GUCY1A1/B1 (soluble guanylate cyclase, NO/cGMP pathway) suggest lipid mediator and gaseous signaling activity. CYP7B1 (steroid/oxysterol metabolism) and LPAR1 (lysophosphatidic acid receptor) add lipid signaling. LSAMP and CLSTN3 are neural adhesion molecules sometimes expressed in fibroblasts. Module is upregulated in both UC and CD inflammation. The dominant theme is complement/TNF-mediated inflammatory fibroblast activation with lipid mediator production.
Genes
ANK2, C3, CLSTN3, CYP7B1, DAAM1, DHRS3, GUCY1A1, GUCY1B1, LPAR1, LSAMP, NFASC, PRRX1, PTGDS, RBP5, SLCO2B1, TNFRSF1B, VGLL3
Most correlated modules
- Neural-crest Fibroblast · correlation 0.78
- Inflammatory Fibroblast Activation · correlation 0.73
- BMP-antagonizing Fibroblast · correlation 0.72
- Subepithelial Fibroblast Identity · correlation 0.70
- Homeostatic Fibroblast Identity · correlation 0.67
- Inflammation-activated ECM · correlation 0.61
- Wnt-niche Fibroblast · correlation 0.58
- FRC function · correlation 0.58
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.