RUNX2 — RUNX family transcription factor 2

RUNX2 belongs to a gene co-expression module in 8 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

RUNX2's module in each cell type

Cell type	Module	Shares the module with
CD19⁺ B cells	Tissue-resident memory B B cell maturation	CALHM2, CCR1, CMTM7, FCRL4, FGD4, GSN, ITGB7, PIK3R6 +4 more	View in SCUBA
CD4⁺ T cells	Gamma-delta T cell Cell contamination	ABHD15, ANKRD28, APOBR, CLIC3, CLIC5, EGLN3, ELOVL6, GLO1 +9 more	View in SCUBA
Fibroblasts	MMP-driven Fibroblast Remodeling ECM remodeling	AKR1B1, ANPEP, COL27A1, COL7A1, CTSL, IL7R, INHBA, MME +4 more	View in SCUBA
Gamma-delta T cells	γδT17 Effector Inflammation	AQP3, CCR6, CEBPD, COLQ, CTSA, CTSH, EDEM2, GCHFR +10 more
Hematopoietic progenitor cells	Regulatory T-cell State Lymphcyte development	CLEC2D, CYTIP, DDIT4, DOCK10, GSTA4, JCHAIN, MDFIC, MEF2A +9 more
Innate lymphoid cells	ILC3 identity Differentiation	ABCC1, BCL6, CCND3, CELF2, CHKB, DNAAF2, ENSG00000285976, EREG +31 more	View in SCUBA
Macrophages	Transcriptional Regulation Housekeeping	ABCC4, ARHGAP12, ATP8B4, CBFA2T2, DLG1, FAM168A, FBXO42, FCHO2 +20 more	View in SCUBA
Mucosal-associated invariant T cell	IL-18 Innate Activation Inflammation	ADAM10, COLQ, IL18RAP, KIF5C, ME1, MYBL1, NEO1, P2RY14 +3 more

About the gene

Synonyms	AML3, CBFA1, CCD, CCD1, PEBP2A1, PEBP2aA1
Chromosome	6: 45328157-45664349
Predicted location	Intracellular
Essential gene	No
Protein class	Disease related genes, Human disease related genes, Predicted intracellular proteins, Transcription factors
Molecular function	DNA-binding
Biological process	Differentiation, Transcription, Transcription regulation

Function

Transcription factor involved in osteoblastic differentiation and skeletal morphogenesis. Essential for the maturation of osteoblasts and both intramembranous and endochondral ossification. CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, osteocalcin, osteopontin, bone sialoprotein, alpha 1(I) collagen, LCK, IL-3 and GM-CSF promoters. In osteoblasts, supports transcription activation: synergizes with SPEN/MINT to enhance FGFR2- mediated activation of the osteocalcin FGF-responsive element (OCFRE) (By similarity). Inhibits KAT6B-dependent transcriptional activation.

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.