PTGER2 — Prostaglandin E receptor 2
PTGER2 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
PTGER2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Cytotoxic Effector CD4 Cytotoxicity | ADAM8, ADRB2, CCL5, CHD9, DPP4, HIC1, HOPX, IFIT2 +13 more | View in SCUBA |
| CD8⁺ T cells | Naive/Memory CD8 T cell maturation | C1orf162, CD48, CD55, EEF1B2, GPR155, IL7R, MATK, MYBL1 +3 more | View in SCUBA |
| Fibroblasts | WNT4+ Stromal Fibroblast Developmental | CARD16, CASP1, FBLIM1, FHL2, GRK5, IQGAP2, OTULINL, PIEZO2 +7 more | View in SCUBA |
| Mucosal-associated invariant T cell | Innate Stress Activation Stress | BATF, BCL2L1, BRD8, DNAJA3, FAM13A, IL6ST, LRRN3, OXNAD1 +5 more |
About the gene
| Synonyms | EP2 |
|---|---|
| Chromosome | 14: 52314305-52328598 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | FDA approved drug targets, G-protein coupled receptors, Human disease related genes, Predicted membrane proteins |
| Molecular function | G-protein coupled receptor, Receptor, Transducer |
Function
Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. The subsequent raise in intracellular cAMP is responsible for the relaxing effect of this receptor on smooth muscle
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.