PROCR — Protein C receptor
PROCR belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
PROCR's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Fibroblasts | WNT4+ Stromal Fibroblast Developmental | CARD16, CASP1, FBLIM1, FHL2, GRK5, IQGAP2, OTULINL, PIEZO2 +7 more | View in SCUBA |
| Lymphatic endothelial | Endothelial Identity endothelial development | ARL6IP5, CLU, ICAM2, LY6E, NTS, NUCB1, PLAAT4, PSIP1 +2 more | View in SCUBA |
| Pericytes | Inflammatory Pericyte Activation Developmental | CDH11, CHN1, EGFL6, NNMT, PRRX1, SERPINF1, TDO2, TYMP | View in SCUBA |
| Smooth muscle cells | Fibroblast Matrisome ECM remodeling | ADAMDEC1, EMP1, FBLN1, LTBP4, NR2F1, PLTP, RGS10, S100A10 +1 more | View in SCUBA |
About the gene
| Synonyms | CCD41, CD201, EPCR |
|---|---|
| Chromosome | 20: 35172072-35216240 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Candidate cardiovascular disease genes, CD markers, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins |
| Molecular function | Receptor |
| Biological process | Blood coagulation, Hemostasis |
Function
Binds activated protein C. Enhances protein C activation by the thrombin-thrombomodulin complex; plays a role in the protein C pathway controlling blood coagulation
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.