Proteasome & OxPhos
Gene co-expression module in Fibroblasts
| Category | Housekeeping |
|---|---|
| Genes | 18 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 11 of 18 genes have a known function matching the annotation |
Why this annotation
The module contains multiple proteasome subunits (PSMB1, PSMA7, PSMB6, PSMB7, PSMC3) alongside OxPhos components (COX7A2, ATP5F1C, NDUFAB1, ATP6V1G1) and antioxidant PRDX1. The proteasome genes are the most numerous coherent sub-program. YBX1 (RNA binding/stress), OAZ1 (polyamine regulation), SUMO1 (SUMOylation), MYL12A (myosin light chain), HINT1 (signaling), GUK1 (nucleotide metabolism). Significantly upregulated in UC inflammation. The proteasome-dominant signature with OxPhos co-regulation suggests a proteostasis/ubiquitin-proteasome housekeeping program. Moderate coherence reflects the mixed OxPhos + proteasome composition. Neighbor to M91/M105 (OxPhos modules) explaining the shared mitochondrial genes.
Genes
ATP5F1C, ATP6V1G1, CNIH1, COX7A2, GUK1, HINT1, MYL12A, NDUFAB1, OAZ1, PRDX1, PSMA7, PSMB1, PSMB6, PSMB7, PSMC3, SARAF, SUMO1, YBX1
Most correlated modules
- ER-Golgi Trafficking · correlation 0.97
- Mitochondrial Energy Metabolism · correlation 0.96
- ER-Golgi Trafficking · correlation 0.96
- Mitochondrial OxPhos · correlation 0.95
- WAVE-RAC1 Actin · correlation 0.94
- ER Secretory Processing · correlation 0.94
- Proteasome Assembly · correlation 0.94
- General Housekeeping · correlation 0.93
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.