Mitochondrial Energy Metabolism
Gene co-expression module in Fibroblasts
| Category | Mitochondrial & OxPhos |
|---|---|
| Genes | 9 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 9 of 9 genes have a known function matching the annotation |
Why this annotation
All hub genes are mitochondrial or metabolic: NDUFA6 (Complex I), ATP5MC3 (Complex V ATP synthase subunit c), COX7B (Complex IV), SLC25A3 (mitochondrial phosphate carrier, essential for ATP synthesis), TOMM20 (TOM complex, mitochondrial protein import), COX5A (Complex IV), MDH2 (TCA cycle), LDHB (lactate dehydrogenase B, pyruvate/lactate interconversion), GAPDH (glycolysis). This module captures both OxPhos and glycolytic/TCA metabolism, representing the broader mitochondrial energy metabolism program. Core coherence, all genes uniformly expressed. Neighbor to M91 (pure OxPhos) — M105 extends the program to include glycolysis and TCA, suggesting coupled energy metabolism.
Genes
ATP5MC3, COX5A, COX7B, GAPDH, LDHB, MDH2, NDUFA6, SLC25A3, TOMM20
Most correlated modules
- Proteasome & OxPhos · correlation 0.96
- Mitochondrial OxPhos · correlation 0.95
- ER-Golgi Trafficking · correlation 0.95
- ER-Golgi Trafficking · correlation 0.94
- Proteasome Assembly · correlation 0.94
- Cullin-RING Ubiquitin Ligase · correlation 0.94
- General Housekeeping · correlation 0.93
- Mitochondrial OXPHOS · correlation 0.93
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.