ER-Golgi Trafficking
Gene co-expression module in Fibroblasts
| Category | Vesicular traficking |
|---|---|
| Genes | 15 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 12 of 15 genes have a known function matching the annotation |
Why this annotation
Hub genes TMED2 and TMED9 are p24 family COPI vesicle cargo receptors mediating ER-to-Golgi trafficking. COPE encodes the epsilon subunit of the COPI coatomer complex. CALR (calreticulin) and PDIA6 are ER chaperones involved in protein folding quality control. DNAJC3 is an ER co-chaperone (P58IPK) that suppresses ER stress. PSMB5 and PSMD8 are proteasome subunits supporting ERAD. MYDGF is an ER-resident protein. EMC7 is part of the ER membrane complex for membrane protein insertion. ARL1 and GDI2 regulate vesicle trafficking. PGAM1 is a glycolytic enzyme. The module is tightly co-regulated (core coherence), uniformly expressed, and significantly upregulated in UC/CD inflammation with reversal in remission, consistent with increased ER secretory demand in activated fibroblasts. Neighbor modules M6 and M98 share ER/proteasome components, confirming a proteostasis neighborhood.
Genes
ARL1, CALR, COPE, DNAJC3, EMC7, GDI2, MPG, MYDGF, PDIA6, PGAM1, PSMB5, PSMD8, TMED2, TMED9, TMEM147
Most correlated modules
- Proteasome & OxPhos · correlation 0.97
- ER Protein Processing · correlation 0.96
- ER Secretory Processing · correlation 0.96
- Proteasome Assembly · correlation 0.96
- ER Protein Folding · correlation 0.95
- ER-Golgi Trafficking · correlation 0.95
- Mitochondrial Energy Metabolism · correlation 0.95
- General Housekeeping · correlation 0.94
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.