SUMO1 — Small ubiquitin like modifier 1
SUMO1 belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
SUMO1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | OxPhos & proteasome Mitochondrial & OxPhos | CCDC167, CLTA, COX17, COX5A, DBI, FKBP1A, FMNL1, GALM +10 more | View in SCUBA |
| Fibroblasts | Proteasome & OxPhos Housekeeping | ATP5F1C, ATP6V1G1, CNIH1, COX7A2, GUK1, HINT1, MYL12A, NDUFAB1 +9 more | View in SCUBA |
| Innate lymphoid cells | SUMOylation Program Protein processing & ER | ATP5MG, ATP6V1G1, BTF3, C4orf3, COX7C, EDF1, EEF1A1, HINT1 +5 more | View in SCUBA |
| Macrophages | Proteasome UPS Housekeeping | ATP6V1D, ATP6V1E1, BAX, C1orf43, COX7A2L, DCUN1D5, DNAJC15, DNAJC8 +28 more | View in SCUBA |
| Smooth muscle cells | Post-translational regulators Housekeeping | ANXA11, BAG1, BANF1, CALM3, CAMTA1, ERH, HMGN3, MYO1C +6 more | View in SCUBA |
About the gene
| Synonyms | GMP1, OFC10, PIC1, SMT3C, SMT3H3, SUMO-1, UBL1 |
|---|---|
| Chromosome | 2: 202206182-202238599 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Predicted intracellular proteins |
| Biological process | Host-virus interaction, Ubl conjugation pathway |
Function
Ubiquitin-like protein that can be covalently attached to proteins as a monomer or a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by E3 ligases such as PIAS1-4, RANBP2 or CBX4. This post- translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Involved for instance in targeting RANGAP1 to the nuclear pore complex protein RANBP2. Covalently attached to the voltage-gated potassium channel KCNB1; this modulates the gating characteristics of KCNB1. Polymeric SUMO1 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins. May also regulate a network of genes involved in palate development. Covalently attached to ZFHX3.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.