ER Secretory Processing
Gene co-expression module in Fibroblasts
| Category | Housekeeping |
|---|---|
| Genes | 11 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 8 of 11 genes have a known function matching the annotation |
Why this annotation
Hub genes include ELOB (elongin B, ubiquitin-like/E3 ligase complex), SSR4 (signal sequence receptor, ER translocation), DAD1 (defender against apoptosis, oligosaccharyltransferase subunit), PPIB (cyclophilin B, ER chaperone/protein folding), SPCS1 (signal peptidase complex), TMEM258 (oligosaccharyltransferase complex), FKBP1A (FK506-binding protein, ER folding), RABAC1 (Rab acceptor), POLR2L (RNA pol II subunit), MYL12B (myosin light chain), TIMP1 (tissue inhibitor of metalloproteinases, ECM). The dominant theme is ER protein processing and secretory pathway (signal peptidase, OST complex, ER chaperones). TIMP1 adds an ECM/fibroblast-relevant dimension. This module reflects ER-based protein secretion and processing, consistent with active fibroblast secretory activity.
Genes
DAD1, ELOB, FKBP1A, MYL12B, POLR2L, PPIB, RABAC1, SPCS1, SSR4, TIMP1, TMEM258
Most correlated modules
- General Housekeeping · correlation 0.97
- Cullin-RING Ubiquitin Ligase · correlation 0.97
- ER-Golgi Trafficking · correlation 0.96
- Rho GTPase Cytoskeletal · correlation 0.95
- Proteasome Assembly · correlation 0.95
- Mitochondrial OXPHOS · correlation 0.94
- Proteasome & OxPhos · correlation 0.94
- ER Protein Processing · correlation 0.93
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.