SCUBA

MYL12A — Myosin light chain 12A

MYL12A belongs to a gene co-expression module in 12 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

MYL12A's module in each cell type

Cell typeModuleShares the module with
CD19⁺ B cellsActin Cytoskeleton
Cytoskeletal
COTL1, GNAI2, HIGD2A, MOB1A, MPG, MYL12B, NDUFB5, PRR13 +8 moreView in SCUBA
CD4⁺ T cellsCell motility/adhesion
migration & adhesion
ANXA2, CCDC107, CYBA, FAM50A, GLIPR2, GRAP2, GYG1, ITM2B +14 moreView in SCUBA
FibroblastsProteasome & OxPhos
Housekeeping
ATP5F1C, ATP6V1G1, CNIH1, COX7A2, GUK1, HINT1, NDUFAB1, OAZ1 +9 moreView in SCUBA
Gamma-delta T cellsT Cell Homeostasis
Housekeeping
ATP6V0E1, CALHM2, CNPY2, CSK, CSTB, DAD1, FERMT3, GTF2H5 +11 more
Goblet cellsActin Dynamics
Cytoskeletal
ABRACL, CD24, CFL1, NDUFB4, NDUFS5, OCIAD2, PIN4, RTRAF +3 moreView in SCUBA
Innate lymphoid cellsAntigen Processing MHC-I
Immune regulation
CMTM6, GUK1, IL2RB, IL4R, PAXX, PSMA5, PSMB8, PSMB9 +8 moreView in SCUBA
Lymphatic endothelialActomyosin Cytoskeleton
Cytoskeletal
BRI3, CD63, CFL1, CHCHD2, COX4I1, EDF1, GABARAPL2, HINT1 +8 moreView in SCUBA
MacrophagesProteasome UPS
Housekeeping
ACP1, ARPC5L, ATP6V1G1, AURKAIP1, C19orf53, CHMP2A, CIAO2B, CIB1 +31 moreView in SCUBA
Mucosal-associated invariant T cellCytotoxic Lymphocyte Program
cytotoxicity
ANXA11, CDKN2D, CYB5A, EMP3, ETHE1, FLT3LG, GLIPR2, LDHB +9 more
Natural Killer cellsNK Cytotoxic Signaling
Cytotoxicity
APOBEC3G, B2M, CALM1, CD48, GLIPR2, HCST, TMSB10, TRGC1 +1 moreView in SCUBA
NeutrophilsMyeloid Identity
Housekeeping
ANP32A, CKLF, CMTM2, HLA-C, HLA-E, IFITM2, ITM2B, LST1 +3 more
Smooth muscle cellsNon-muscle Actomyosin
Cytoskeletal
C1R, CAST, CD63, CLIC1, DYNLL1, FILIP1L, LDHA, LIMS1 +4 moreView in SCUBA

About the gene

SynonymsMLCB, MRCL3, MRLC3, MYL2B
Chromosome18: 3247481-3256236
Predicted locationIntracellular
Essential geneNo
Protein classPredicted intracellular proteins
Molecular functionMotor protein, Muscle protein, Myosin

Function

Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation. Implicated in cytokinesis, receptor capping, and cell locomotion (By similarity)

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.