Proteasome Assembly
Gene co-expression module in Fibroblasts
| Category | Housekeeping |
|---|---|
| Genes | 13 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 6 of 13 genes have a known function matching the annotation |
Why this annotation
The top hub genes by PageRank are PSMA3 and PSMA5 (proteasome 20S alpha subunits), with PSMA4 also present — three proteasome alpha subunits dominate this module. MANF (mesencephalic astrocyte-derived neurotrophic factor) is an ER stress-protective protein induced by UPR. C1QBP is a multifunctional protein with roles in mitochondria and ER stress. PRELID1 transfers phosphatidic acid in mitochondria. NDUFV2 is Complex I subunit. VDAC1 is the mitochondrial outer membrane voltage-dependent anion channel. MRPL52 is a mitoribosomal protein. ATOX1 is a copper chaperone. DBI (diazepam binding inhibitor) is involved in lipid metabolism. PDCD5 promotes apoptosis. Despite mitochondrial members, the three proteasome alpha subunits as top hubs and the neighbor context (M6 has PSMD7/PSMC4, M98 has POMP) place this firmly in the proteasome assembly program, with mitochondrial genes as co-regulated secondary members reflecting general metabolic activation.
Genes
ATOX1, C1QBP, DBI, DYNLT1, MANF, MRPL52, NDUFV2, PDCD5, PRELID1, PSMA3, PSMA4, PSMA5, VDAC1
Most correlated modules
- Proteasome Biogenesis · correlation 0.97
- ER Protein Processing · correlation 0.97
- ER-Golgi Trafficking · correlation 0.96
- Lysosomal Stress Response · correlation 0.95
- ER Secretory Processing · correlation 0.95
- Cullin-RING Ubiquitin Ligase · correlation 0.94
- Mitochondrial Energy Metabolism · correlation 0.94
- Proteasome & OxPhos · correlation 0.94
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.