PRDX1 — Peroxiredoxin 1
PRDX1 belongs to a gene co-expression module in 13 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
PRDX1's module in each cell type
About the gene
| Synonyms | NKEFA, PAGA |
|---|---|
| Chromosome | 1: 45510914-45542732 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins |
| Molecular function | Antioxidant, Oxidoreductase, Peroxidase |
Function
Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2). Reduces an intramolecular disulfide bond in GDPD5 that gates the ability to GDPD5 to drive postmitotic motor neuron differentiation (By similarity)
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.