Homeostatic Fibroblast State
Gene co-expression module in Fibroblasts
| Category | Housekeeping |
|---|---|
| Genes | 14 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 10 of 14 genes have a known function matching the annotation |
Why this annotation
Hub genes include CCL13, CCL8 (homeostatic chemokines), APOE, FABP4, FABP5 (lipid metabolism), FGFR2 (growth factor signaling), PLPP3 (phospholipid phosphatase), and COLEC11 (complement lectin). The module is strongly downregulated in UC inflammation and restored in remission, consistent with a homeostatic fibroblast state. The combination of chemokine expression and lipid metabolism genes is characteristic of quiescent lamina propria fibroblasts that maintain mucosal homeostasis.
Genes
ADAM28, APOE, CCL13, CCL8, COLEC11, CRYBG3, ELANE, FABP4, FABP5, FGFR2, GGT5, PLPP3, SCT, TMEM150C
Most correlated modules
- Stromal Niche Signaling · correlation 0.85
- CCL11 Secretory Fibroblast · correlation 0.81
- Subepithelial Fibroblast · correlation 0.79
- CYGB+ Quiescent Fibroblast · correlation 0.71
- COL13A1+ Deep Fibroblast · correlation 0.70
- Elastic Fiber ECM · correlation 0.64
- Interferon Response · correlation 0.64
- ASPN+ Submucosal Fibroblast · correlation 0.54
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.