Microfibril ECM Fibroblast
Gene co-expression module in Fibroblasts
| Category | ECM production |
|---|---|
| Genes | 11 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 8 of 11 genes have a known function matching the annotation |
Why this annotation
Hub genes MFAP4 (microfibril-associated protein, marks specific fibroblast/smooth muscle subsets), PROS1 (anticoagulant and TAM receptor ligand), OLFML1 (olfactomedin-like ECM), CD302 (lectin receptor), EPHX1 (xenobiotic/lipid metabolism), NFIX (transcription factor for stromal identity), and CYBRD1 (iron metabolism) define a specialized fibroblast subtype with microfibril ECM and metabolic identity features. MFAP4 and OLFML1 are enriched in specific intestinal fibroblast subpopulations. Downregulated in UC inflammation, restored in remission.
Genes
CD302, CD81, COX7C, CYBRD1, EPHX1, MFAP4, NFIX, NOP53, NUCKS1, OLFML1, PROS1
Most correlated modules
- Quiescent Stromal Identity · correlation 0.89
- Elastic Fiber ECM · correlation 0.81
- Subepithelial Fibroblast Identity · correlation 0.79
- Subepithelial Fibroblast · correlation 0.79
- Elastin-Fibronectin ECM · correlation 0.79
- Homeostatic Fibroblast Identity · correlation 0.78
- Stromal Niche Signaling · correlation 0.77
- Complement-secreting Fibroblast · correlation 0.76
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.