Smooth Muscle Differentiation
Gene co-expression module in Fibroblasts
| Category | Developmental |
|---|---|
| Genes | 9 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 8 of 9 genes have a known function matching the annotation |
Why this annotation
Hub genes CKB (creatine kinase B, energy buffering in muscle), PGM5 (phosphoglucomutase 5, muscle-specific), ASB2 (ankyrin repeat/SOCS box, promotes muscle differentiation via filamin degradation), DYSF (dysferlin, muscle membrane repair), FLNC (filamin C, striated/smooth muscle-specific), LIMS2 (muscle LIM protein 2), ADCY5 (adenylyl cyclase 5, cardiac/smooth muscle), CABP1 (calcium-binding protein). This is a highly specific muscle differentiation signature. Very low expression/pct positive (4.2%) suggests a rare, highly differentiated smooth muscle-like fibroblast subpopulation. Upregulated in remission, suggesting this mature contractile state is suppressed during active inflammation. Neighbor of M94 (smooth muscle program), supporting a related but more differentiated muscle identity.
Genes
ADCY5, ASB2, CABP1, CKB, DYSF, FLNC, LIMS2, PGM5, TMEM35A
Most correlated modules
- Smooth Muscle Identity · correlation 0.88
- ICC contractility · correlation 0.85
- ICC electrophysiological machinery · correlation 0.83
- Myofibroblast Contractile · correlation 0.78
- BMP-Wnt Niche Signaling · correlation 0.75
- Notch Fibroblast Activation · correlation 0.74
- ICC neuromuscular junction · correlation 0.69
- TGF-beta Fibroblast Niche · correlation 0.68
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.