Focal Adhesion ECM
Gene co-expression module in Fibroblasts
| Category | Migration & adhesion |
|---|---|
| Genes | 15 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 11 of 15 genes have a known function matching the annotation |
Why this annotation
Hub genes WDR1 (AIP1/actin interacting protein 1, actin dynamics with cofilin), ACTN1 (alpha-actinin 1, actin crosslinker/focal adhesion), COL4A1 and COL4A2 (type IV collagen, basement membrane), VCL (vinculin, focal adhesion), MYL6 (myosin light chain 6), TPM2 (tropomyosin 2), PARVA (parvin alpha, focal adhesion/ILK complex), VASP (vasodilator-stimulated phosphoprotein, actin polymerization at focal adhesions), CLIC4 (chloride intracellular channel), ZYX (zyxin, focal adhesion), MPRIP (myosin phosphatase Rho-interacting protein). This module combines focal adhesion machinery with basement membrane collagen production, consistent with a fibroblast program supporting ECM anchorage and basement membrane deposition. Significantly upregulated in UC and CD inflammation.
Genes
ACTN1, CLIC4, COL4A1, COL4A2, MPRIP, MRPL33, MYL6, NDUFA4, PARVA, POLE4, TPM2, VASP, VCL, WDR1, ZYX
Most correlated modules
- Actin-Integrin Adhesion · correlation 0.94
- Caveolae Mechanosensing · correlation 0.92
- Rho-ROCK Contractility · correlation 0.90
- Myofibroblast Contractile · correlation 0.89
- Notch Fibroblast Activation · correlation 0.88
- Actin Cytoskeleton · correlation 0.87
- Smooth Muscle Identity · correlation 0.75
- Stromal Niche Identity · correlation 0.75
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.