Notch Fibroblast Activation
Gene co-expression module in Fibroblasts
| Category | Developmental |
|---|---|
| Genes | 11 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 8 of 11 genes have a known function matching the annotation |
Why this annotation
Hub genes include RBPJ (canonical Notch transcriptional effector), FHL1 (LIM domain cytoskeletal adaptor), TLN1 (talin, focal adhesion), CORO1C (actin dynamics), DSTN (actin depolymerizing factor), PDLIM5 (PDZ-LIM cytoskeletal), and DIXDC1 (Wnt/cytoskeletal signaling). RBPJ is the master Notch transcriptional mediator; its co-expression with cytoskeletal/LIM-domain genes (FHL1, PDLIM5, TLN1, CORO1C, DSTN) in inflamed intestinal fibroblasts suggests a Notch-driven fibroblast activation state. Upregulated significantly in UC and CD inflammation. Neighbor context: sits adjacent to contractile/myofibroblast modules (M63, M94), consistent with a Notch-regulated fibroblast activation program feeding into contractile identity.
Genes
CORO1C, DIXDC1, DSTN, FHL1, MRGPRF, PDLIM5, RBPJ, SH3BGRL, TCEAL3, TCEAL4, TLN1
Most correlated modules
- Myofibroblast Contractile · correlation 0.92
- Caveolae Mechanosensing · correlation 0.91
- Focal Adhesion ECM · correlation 0.88
- Rho-ROCK Contractility · correlation 0.87
- TGF-beta Fibroblast Niche · correlation 0.86
- ECM Homeostasis · correlation 0.83
- Smooth Muscle Identity · correlation 0.83
- Stromal Niche Identity · correlation 0.77
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.