Caveolae Mechanosensing
Gene co-expression module in Fibroblasts
| Category | Migration & adhesion |
|---|---|
| Genes | 15 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 9 of 15 genes have a known function matching the annotation |
Why this annotation
Hub genes PLEKHO1 (pleckstrin homology domain), TES (testin, focal adhesion LIM protein, tumor suppressor), SVIL (supervillin, actin/myosin II cortex organizer), FNBP1 (formin-binding protein, actin nucleation), PHLDB2 (pleckstrin homology-like domain, lamellipodia), CAVIN1 (PTRF/cavin-1, caveolae biogenesis), KLHL5, MAP3K20 (ZAK kinase, stress-activated), TNS1 (tensin 1, focal adhesion/actin), PDLIM3 (PDZ-LIM, actin cytoskeleton), TGM2 (transglutaminase 2, ECM crosslinking/integrin binding), SCARA3 (scavenger receptor). Strong upregulation in both UC and CD inflammation. The combination of caveolae (CAVIN1), focal adhesion (TES, TNS1, PDLIM3), actin cortex (SVIL, FNBP1), and ECM crosslinking (TGM2) defines a mechanosensing/caveolae-focal adhesion program in activated fibroblasts.
Genes
CAVIN1, FNBP1, KLHL5, LDLRAD3, MAP3K20, PDLIM3, PHLDB2, PLEKHO1, PLP2, RABGAP1, SCARA3, SVIL, TES, TGM2, TNS1
Most correlated modules
- Focal Adhesion ECM · correlation 0.92
- Notch Fibroblast Activation · correlation 0.91
- Myofibroblast Contractile · correlation 0.88
- Rho-ROCK Contractility · correlation 0.80
- Smooth Muscle Identity · correlation 0.80
- TGF-beta Fibroblast Niche · correlation 0.78
- Stromal Niche Identity · correlation 0.75
- Smooth Muscle Differentiation · correlation 0.65
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.