Smooth Muscle Identity
Gene co-expression module in Fibroblasts
| Category | Cytoskeletal |
|---|---|
| Genes | 21 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 13 of 21 genes have a known function matching the annotation |
Why this annotation
Core coherence module dominated by definitive smooth muscle differentiation markers: MYH11 (smooth muscle myosin heavy chain, gold-standard SMC marker), CNN1 (calponin 1, smooth muscle), ACTG2 (gamma-2 actin, smooth muscle-specific), LMOD1 (leiomodin 1, smooth muscle), SMTN (smoothelin, smooth muscle), PLN (phospholamban, smooth muscle/cardiac), KCNMB1 (BK channel beta-1, smooth muscle), SORBS1 (sorbin, smooth muscle cytoskeleton), SYNPO2 (synaptopodin 2, smooth muscle), JPH2 (junctophilin 2), SLMAP (sarcolemmal membrane-associated), FBXL22, PPP1R12B (myosin phosphatase), MCAM (CD146, pericyte/SMC marker). This represents a more terminally differentiated smooth muscle cell program compared to M63. Upregulated in UC inflammation. Neighbor of M63 and M113, forming a gradient of smooth muscle differentiation.
Genes
ACTG2, ALDH1B1, C3orf70, CNN1, FBXL22, HSD17B6, JPH2, KCNH2, KCNMB1, LMOD1, MCAM, MTCL1, MYH11, PAWR, PLN, PPP1R12B, SLC2A4, SLMAP, SMTN, SORBS1, SYNPO2
Most correlated modules
- Myofibroblast Contractile · correlation 0.92
- Stromal Niche Identity · correlation 0.89
- Smooth Muscle Differentiation · correlation 0.88
- BMP-Wnt Niche Signaling · correlation 0.83
- Notch Fibroblast Activation · correlation 0.83
- Caveolae Mechanosensing · correlation 0.80
- TGF-beta Fibroblast Niche · correlation 0.76
- ICC contractility · correlation 0.76
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.