BMP-Wnt Niche Signaling
Gene co-expression module in Fibroblasts
| Category | Developmental |
|---|---|
| Genes | 17 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 5 of 17 genes have a known function matching the annotation |
Why this annotation
NPNT (nephronectin, ECM glycoprotein and integrin ligand), SOSTDC1 (BMP/Wnt antagonist expressed in intestinal stromal niche cells), ITGA9 (integrin alpha-9, ECM receptor), and MSTN (TGF-beta superfamily member) define an ECM-integrin signaling and stromal niche program. Very low expression (1.1% positive) and strong remission upregulation (delta_remission_UC: 0.684, delta_remission_CD: 0.463) parallel M59, suggesting a related quiescent homeostatic stromal state. SOSTDC1 is a well-established marker of intestinal subepithelial fibroblasts involved in crypt niche regulation.
Genes
CHMP4C, DCAF12L1, DIRAS1, DPEP2, GIPC3, ITGA9, LUZP2, MSTN, MYEF2, NPNT, RAB9B, SEZ6L, SLC30A8, SOSTDC1, SYT10, TRDN, TSPAN15
Most correlated modules
- Stromal Niche Identity · correlation 0.84
- Smooth Muscle Identity · correlation 0.83
- Myofibroblast Contractile · correlation 0.76
- Smooth Muscle Differentiation · correlation 0.75
- TGF-beta Fibroblast Niche · correlation 0.71
- Notch Fibroblast Activation · correlation 0.71
- Wnt-Niche Fibroblast · correlation 0.59
- ICC contractility · correlation 0.49
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.