Cullin-RING Ubiquitin Ligase
Gene co-expression module in Fibroblasts
| Category | Housekeeping |
|---|---|
| Genes | 12 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 10 of 12 genes have a known function matching the annotation |
Why this annotation
Hub genes include SEM1 (26S proteasome regulatory subunit), RNF7 (RING finger E3 ubiquitin ligase), RBX1 (RING-box protein, cullin-RING ligase), NEDD8 neighbor context (neddylation activates cullin-RING ligases), NDUFB11/NDUFA11/NDUFC2/UQCRH (mitochondrial respiratory chain complex I/III subunits), MRPL51 (mitochondrial ribosomal protein), OST4 (oligosaccharyltransferase), TRMT112 (tRNA/rRNA methyltransferase), ARPC3 (Arp2/3 complex, actin branching), LAMTOR5 (mTORC1/lysosomal signaling). The module mixes ubiquitin-proteasome/cullin-RING ligase components with mitochondrial OXPHOS subunits. Given the neighbor context (M66 is a pure OXPHOS module), the mitochondrial genes here are likely co-regulated. The dominant theme bridging both programs is general cellular energy and proteostasis — but the cullin-RING/neddylation axis (SEM1, RNF7, RBX1) is the most distinctive feature. Classifying as ubiquitin-proteasome/proteostasis with mitochondrial co-expression.
Genes
ARPC3, LAMTOR5, MRPL51, NDUFA11, NDUFB11, NDUFC2, OST4, RBX1, RNF7, SEM1, TRMT112, UQCRH
Most correlated modules
- ER Secretory Processing · correlation 0.97
- General Housekeeping · correlation 0.97
- Mitochondrial OXPHOS · correlation 0.95
- Proteasome Assembly · correlation 0.94
- Proteasome Biogenesis · correlation 0.94
- Mitochondrial Energy Metabolism · correlation 0.94
- Rho GTPase Cytoskeletal · correlation 0.93
- ER-Golgi Trafficking · correlation 0.93
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.