Electron Transport Chain
Gene co-expression module in Gamma-delta T cells
| Category | Mitochondrial & OxPhos |
|---|---|
| Genes | 15 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 8 of 15 genes have a known function matching the annotation |
Why this annotation
This module is tightly anchored on the electron transport chain: UQCRH (ubiquinol-cytochrome c reductase hinge protein, Complex III), COX7A2 and COX5B (cytochrome c oxidase subunits, Complex IV), NDUFA4 (NADH:ubiquinone oxidoreductase subunit A4, Complex IV accessory), NDUFB4 (Complex I subunit), PET100 (COX assembly chaperone), TOMM5 (outer mitochondrial membrane translocase). NME2 (nucleoside diphosphate kinase) supports mitochondrial nucleotide homeostasis. MIF and SRP14 are peripheral. The module is a strong, coherent OxPhos/ETC gene set, consistent with the neighboring modules in this batch.
Genes
ARL6IP4, BBLN, C19orf53, COX5B, COX7A2, MIF, NDUFA4, NDUFB4, NME2, PET100, RCN2, RPP21, SRP14, TOMM5, UQCRH
Most correlated modules
- Oxidative Phosphorylation · correlation 0.91
- Mitochondrial ETC · correlation 0.84
- ATP Synthase Complex · correlation 0.81
- Translation Initiation · correlation 0.81
- Transcriptional Elongation Control · correlation 0.80
- snRNP Splicing · correlation 0.80
- Chaperone Protein Folding · correlation 0.79
- Mitochondrial Dynamics · correlation 0.77
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.