Mitochondrial Dynamics
Gene co-expression module in Gamma-delta T cells
| Category | Mitochondrial & OxPhos |
|---|---|
| Genes | 11 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 6 of 11 genes have a known function matching the annotation |
Why this annotation
Hub genes strongly point to mitochondrial structure and function: FIS1 (mitochondrial fission protein 1), MICOS13 (mitochondrial inner membrane contact site complex subunit), ATP5MC1 (ATP synthase membrane subunit c, Complex V), HIGD2A (HIG domain protein 2A, involved in Complex IV assembly under hypoxia), ECHS1 (short-chain enoyl-CoA hydratase, mitochondrial fatty acid beta-oxidation). SELENOH is a nuclear selenoprotein involved in redox regulation. MTAP is involved in polyamine/adenosine metabolism. This module is centered on mitochondrial inner membrane organization, OxPhos assembly, and mitochondrial dynamics, tightly consistent with the neighboring OxPhos modules in this batch.
Genes
ATP5MC1, ECHS1, EDF1, FIS1, FRA10AC1, HIGD2A, IFNAR2, MICOS13, MRI1, MTAP, SELENOH
Most correlated modules
- Mitochondrial Housekeeping · correlation 0.88
- ATP Synthase Complex · correlation 0.88
- Mitochondrial Ribosome · correlation 0.85
- Mitochondrial Translation · correlation 0.83
- Oxidative Phosphorylation · correlation 0.81
- Metabolic Housekeeping · correlation 0.80
- Mitochondrial Biogenesis · correlation 0.79
- Mitoribosome Small Subunit · correlation 0.79
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.