Translation Initiation
Gene co-expression module in Gamma-delta T cells
| Category | RNA processing & translation |
|---|---|
| Genes | 27 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 11 of 27 genes have a known function matching the annotation |
Why this annotation
This module is dominated by translation machinery: EIF3F, EIF3L, EIF3H, EIF3K, EIF3E (eukaryotic initiation factor 3 subunits), EEF1D, EEF1B2, EEF1G (translation elongation factors), UBA52 and FAU (ubiquitin-ribosomal protein fusions, structural components of the ribosome), BTF3 (nascent polypeptide-associated complex beta subunit). COX7C and COX4I1 (Complex IV) and TOMM7 (TOM complex) are OxPhos neighbors co-expressed in these highly active cells. SEC61G (ER translocon), PFDN5 (prefoldin chaperone), ERGIC3 (ER-Golgi), SNRPD2 (spliceosome), COMMD6 are peripheral. The eIF3 complex dominance (5 subunits) makes this a clear translation initiation module.
Genes
BTF3, C12orf57, COMMD6, COX4I1, COX7C, EEF1B2, EEF1D, EEF1G, EIF3E, EIF3F, EIF3H, EIF3K, EIF3L, ERGIC3, FAU, NSA2, PFDN5, SEC61B, SEC61G, SLC25A6, SNRPD2, SPCS1, TOMM7, UBA52, UBXN1, UQCRB, UXT
Most correlated modules
- Electron Transport Chain · correlation 0.81
- Mitochondrial Ribosome · correlation 0.80
- Mitochondrial Biogenesis · correlation 0.77
- Protein Homeostasis Chaperones · correlation 0.76
- Death Receptor Apoptosis · correlation 0.66
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.