Oxidative Phosphorylation
Gene co-expression module in Gamma-delta T cells
| Category | Mitochondrial & OxPhos |
|---|---|
| Genes | 21 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 11 of 21 genes have a known function matching the annotation |
Why this annotation
This is a tightly coherent (core) module with nearly all genes showing core membership. Hub genes include NDUFA11, NDUFA1, NDUFA13, NDUFB8 — all subunits of mitochondrial Complex I (NADH:ubiquinone oxidoreductase) — and COX6B1, COX6C, COX6A1 — subunits of Complex IV (cytochrome c oxidase). This definitively identifies an oxidative phosphorylation (OxPhos) program. PSMA7, PSMA2, PSME1 are proteasome subunits that frequently co-vary with OxPhos in actively metabolizing cells. CSNK2B (CK2 beta) phosphorylates many metabolic regulators. ARPC4 and ARPC1B (Arp2/3 complex) and COPE (COPI) are additional constitutive programs co-varying in active cells. ATP6V1F (V-ATPase) supports mitochondrial membrane potential. NEDD8 regulates cullin-RING ubiquitin ligases. The OxPhos identity dominates with 7 direct ETC subunits across two complexes at the top of the ranked list.
Genes
ARPC1B, ARPC4, ATP6V1F, COPE, COX6A1, COX6B1, COX6C, CSNK2B, NDUFA1, NDUFA11, NDUFA13, NDUFB8, NEDD8, PSMA2, PSMA7, PSME1, SERF2, TMA7, TMEM258, UBL5, WDR83OS
Most correlated modules
- Electron Transport Chain · correlation 0.91
- General Housekeeping Mixed · correlation 0.90
- Complex I Assembly · correlation 0.88
- Basal Cell Maintenance · correlation 0.86
- Mitochondrial Housekeeping · correlation 0.86
- Transcriptional Elongation Control · correlation 0.85
- Chaperone Protein Folding · correlation 0.84
- Mitochondrial Translation · correlation 0.84
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.