Mitochondrial ETC
Gene co-expression module in Gamma-delta T cells
| Category | Mitochondrial & OxPhos |
|---|---|
| Genes | 14 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 4 of 14 genes have a known function matching the annotation |
Why this annotation
Hub genes COX7B, ROMO1, UQCRQ, NDUFB6 are mitochondrial electron transport chain components (Complex I, III, IV), supported by chromatin-associated HMGN1/HMGB1 and RNA processing genes. The top PageRank genes are primarily ETC/mitochondrial, with uniform expression consistent with housekeeping metabolic activity. Neighbor modules M65 and M73 share ETC components, confirming a housekeeping metabolic neighborhood.
Genes
COX7B, HMGB1, HMGN1, HMGXB4, LSM5, NDUFB6, PSMA6, RANGRF, RBM17, RBM42, ROMO1, SNRPG, UQCRQ, YBX1
Most correlated modules
- snRNP Splicing · correlation 0.88
- Mitochondrial OxPhos · correlation 0.86
- Cellular Homeostasis · correlation 0.86
- Electron Transport Chain · correlation 0.84
- Transcriptional Elongation Control · correlation 0.82
- G1/S Entry · correlation 0.82
- Proteasome Complex · correlation 0.80
- RNA Binding/Splicing · correlation 0.80
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.