SCUBA

NDUFB4 — NADH:ubiquinone oxidoreductase subunit B4

NDUFB4 belongs to a gene co-expression module in 8 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

NDUFB4's module in each cell type

Cell typeModuleShares the module with
CD4⁺ T cellsOxidative Phosphorylation
Mitochondrial & OxPhos
AP2S1, ATP5F1C, ATP5PF, COPS9, COX6B1, EID1, FAM89B, FDPS +19 moreView in SCUBA
CD8⁺ T cellsProteasome Degradation
Housekeeping
ARPP19, CLTA, GNG5, HSBP1, POLR2J, POLR2K, PSMB2, PSMB3 +2 moreView in SCUBA
FibroblastsMitochondrial OxPhos
Mitochondrial & OxPhos
ATP5PF, COX6A1, COX6C, GSTP1, MGST3, NDUFA12, NDUFA8, NDUFB10 +6 moreView in SCUBA
Gamma-delta T cellsElectron Transport Chain
Mitochondrial & OxPhos
ARL6IP4, BBLN, C19orf53, COX5B, COX7A2, MIF, NDUFA4, NME2 +6 more
Goblet cellsActin Dynamics
Cytoskeletal
ABRACL, CD24, CFL1, MYL12A, NDUFS5, OCIAD2, PIN4, RTRAF +3 moreView in SCUBA
Innate lymphoid cellsMixed Proteostasis Metabolism
Metabolism
ADRM1, ANXA11, ATP6V0B, CISD2, COX17, DNAJC8, DR1, EIF3I +18 moreView in SCUBA
Lymphatic endothelialMitochondrial OxPhos Complex
Mitochondrial & OxPhos
COX6A1, COX6B1, COX6C, COX7A2, COX8A, DAD1, NDUFA1, NDUFB5 +6 moreView in SCUBA
MacrophagesGlycolytic Redox Metabolism
Lipid metabolism
AGPAT2, ANXA5, ATP6V1F, BCKDK, BRI3, C1orf122, CLIC1, ELOC +18 moreView in SCUBA

About the gene

SynonymsB15
Chromosome3: 120596328-120602507
Predicted locationIntracellular, Membrane
Essential geneYes
Protein classEssential proteins, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins
Biological processElectron transport, Respiratory chain, Transport

Function

Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.