Cell Cycle Entry
Gene co-expression module in Gamma-delta T cells
| Category | Cell cycle |
|---|---|
| Genes | 13 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 8 of 13 genes have a known function matching the annotation |
Why this annotation
Hub genes CDK4 (G1/S cyclin-dependent kinase), DCTPP1 (dCTP pyrophosphatase, nucleotide pool regulation), PAICS (de novo purine synthesis), UNG (uracil-DNA glycosylase, active during S phase), NME1 (nucleoside diphosphate kinase, proliferation marker), and MTHFD1 (folate-mediated one-carbon metabolism supporting dTMP synthesis) together define an S-phase entry and nucleotide biosynthesis program. FH (TCA) and GSS (glutathione) provide supporting metabolic context. The module reflects proliferating gd-T cells preparing for DNA replication.
Genes
CDK4, DCTPP1, FH, GGCT, GSS, ISOC2, MBD3, MTHFD1, NABP2, NME1, PAICS, PSMG1, UNG
Most correlated modules
- Cellular Homeostasis · correlation 0.87
- Mitochondrial OxPhos · correlation 0.87
- DNA Replication Licensing · correlation 0.86
- Basal Lipid Metabolism · correlation 0.80
- S-phase Replication · correlation 0.75
- DNA Repair Housekeeping · correlation 0.67
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.