GGCT — Gamma-glutamylcyclotransferase
GGCT belongs to a gene co-expression module in 7 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
GGCT's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | RNA Processing RNA processing | ANP32A, CCDC167, CDK4, CENPX, CYC1, FDPS, LSM3, LSM4 +14 more | View in SCUBA |
| CD8⁺ T cells | RNA & Redox Housekeeping RNA processing & translation | ANP32A, C11orf58, CCT6A, COPRS, DPM2, GLRX3, LAGE3, NME1 +3 more | View in SCUBA |
| Endothelial | ER-Golgi Trafficking Protein processing & ER | ARPC1A, CCT8, FIBP, GDI2, LMAN2, MAP2K2, MRPS16, PAICS +10 more | View in SCUBA |
| Fibroblasts | Inflammatory ECM Remodeling ECM remodeling | ABRACL, ADAMTS2, CD82, CHI3L1, COTL1, LXN, MT2A, NID2 +5 more | View in SCUBA |
| Gamma-delta T cells | Cell Cycle Entry Cell cycle | CDK4, DCTPP1, FH, GSS, ISOC2, MBD3, MTHFD1, NABP2 +4 more | |
| Innate lymphoid cells | Mitochondrial Metabolic Housekeeping Mitochondrial & OxPhos | ALKBH7, ATF6B, BCAS1, COQ8A, DDT, DNAJC4, DPM3, EIF3M +16 more | View in SCUBA |
| Macrophages | Mitotic Spindle Assembly Cell cycle | ACTL6A, AKR7A2, ANP32E, BOLA3, BUB3, CCDC167, CENPW, CENPX +34 more | View in SCUBA |
About the gene
| Synonyms | C7orf24, CRF21, GCTG, Ggc, MGC3077 |
|---|---|
| Chromosome | 7: 30496621-30504841 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins |
| Molecular function | Lyase |
Function
Catalyzes the formation of 5-oxoproline from gamma-glutamyl dipeptides and may play a significant role in glutathione homeostasis. Induces release of cytochrome c from mitochondria with resultant induction of apoptosis
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.