Basal Lipid Metabolism
Gene co-expression module in Gamma-delta T cells
| Category | Housekeeping |
|---|---|
| Genes | 15 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 8 of 15 genes have a known function matching the annotation |
Why this annotation
Hub genes include ACOT7 (acyl-CoA thioesterase), MGLL (monoglyceride lipase), SPTSSA (sphingolipid synthesis), AHCY (methionine cycle), SHMT1 (one-carbon metabolism), MPST (sulfur metabolism), and DNA repair genes SMC6 and FANCL. The module is uniformly expressed at very low levels (6.8% positive) with no subset enrichment, suggesting basal metabolic housekeeping activity. The combination of lipid catabolism, one-carbon/methionine cycling, and sulfur metabolism reflects constitutive metabolic enzyme expression rather than a stimulus-driven program.
Genes
ACOT7, ADCY3, AHCY, CLN6, DENND6B, FANCL, MGLL, MPST, NUDT8, SHMT1, SLC43A3, SMC6, SPTSSA, TMEM167A, TSPAN5
Most correlated modules
- Mitochondrial OxPhos · correlation 0.86
- Tissue Resident CD103+ · correlation 0.83
- DNA Repair Housekeeping · correlation 0.83
- Cell Cycle Entry · correlation 0.80
- G1/S Entry · correlation 0.80
- DNA Replication Licensing · correlation 0.79
- Pre-mRNA Splicing · correlation 0.78
- NK Receptor Expression · correlation 0.77
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.