PSMG1 — Proteasome assembly chaperone 1
PSMG1 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
PSMG1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | Glycolysis Biosynthesis Mitochondrial & OxPhos | EIF3I, FABP5, LDHA, MDH1, MRPL17, PAICS, PKM, POLD2 +4 more | View in SCUBA |
| Gamma-delta T cells | Cell Cycle Entry Cell cycle | CDK4, DCTPP1, FH, GGCT, GSS, ISOC2, MBD3, MTHFD1 +4 more | |
| Hematopoietic progenitor cells | RNA Processing Housekeeping Housekeeping | ATP5MC1, C1QBP, CDK4, DUT, FABP5, HSPE1, LSM5, NDUFAF8 +8 more |
About the gene
| Synonyms | c21-LRP, DSCR2, LRPC21, PAC1 |
|---|---|
| Chromosome | 21: 39174769-39183488 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Molecular function | Chaperone |
Function
Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with PSMG2. The PSMG1-PSMG2 heterodimer binds to the PSMA5 and PSMA7 proteasome subunits, promotes assembly of the proteasome alpha subunits into the heteroheptameric alpha ring and prevents alpha ring dimerization
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.