DNA Repair Housekeeping
Gene co-expression module in Gamma-delta T cells
| Category | Housekeeping |
|---|---|
| Genes | 19 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 8 of 19 genes have a known function matching the annotation |
Why this annotation
Hub genes include ECH1 (beta-oxidation), ERCC1 and MPG (DNA repair), LSM2 and TRPT1 (RNA processing), TIMM13 (mitochondrial import), ANAPC16 (APC/C, cell cycle), and DNAJC4 (chaperone). Despite strong coherence, the module combines multiple low-level housekeeping programs. LGALS9 (galectin-9) and CKLF add immune signaling context but are peripheral. The uniform, moderate expression (24.6%) with no subset enrichment supports a general housekeeping classification. Neighbor context with M24 and M74 reinforces basal metabolic/maintenance programs.
Genes
ANAPC16, CCDC85B, CDIP1, CKLF, COTL1, DNAJC4, ECH1, ERCC1, IFT27, LGALS9, LSM2, MPG, P2RX4, PHYKPL, RGL4, SUSD3, TIMM13, TMEM14C, TRPT1
Most correlated modules
- Mitochondrial OxPhos · correlation 0.87
- Metabolic Housekeeping · correlation 0.83
- Basal Lipid Metabolism · correlation 0.83
- Tissue Resident CD103+ · correlation 0.81
- Gut-homing Residence · correlation 0.79
- Actin-based Motility · correlation 0.78
- Immature T Cell · correlation 0.78
- Ubiquitin-Proteasome Trafficking · correlation 0.73
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.