ECM Homeostatic Regulation
Gene co-expression module in Glial cells
| Category | ECM remodeling |
|---|---|
| Genes | 8 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 6 of 8 genes have a known function matching the annotation |
Why this annotation
Hub genes include SASH1 (scaffold/signaling adaptor, tumor suppressor, stress signaling), OAF (out at first homolog, transcription regulator), MAPRE2 (microtubule end-binding protein EB2, microtubule dynamics), TIMP2 (tissue inhibitor of metalloproteinases 2, ECM remodeling/homeostasis), KCTD12 (potassium channel tetramerization domain, modulates GABA-B receptor), BPTF (chromatin remodeling, NURF complex), TTC3 (E3 ubiquitin ligase, neurodevelopment), ST3GAL6 (sialyltransferase, glycan modification). Significantly downregulated in UC inflammation, restored at remission. The combination of TIMP2 (ECM regulation), MAPRE2 (cytoskeletal dynamics), SASH1 (scaffold signaling), and chromatin/epigenetic factors (BPTF) suggests a homeostatic glial program involved in ECM regulation and cytoskeletal maintenance. TIMP2 is the clearest ECM-related gene; together with neighbors M48 and M21 (both glial homeostatic), this module likely represents a glial ECM-regulatory homeostatic state.
Genes
BPTF, KCTD12, MAPRE2, OAF, SASH1, ST3GAL6, TIMP2, TTC3
Most correlated modules
- Glial Homeostatic Identity · correlation 0.89
- Glial Adhesion Identity · correlation 0.83
- Glial Synaptic Adhesion · correlation 0.82
- Glial Vesicle Trafficking · correlation 0.82
- Lysosomal Sphingolipid Metabolism · correlation 0.81
- Enteric Glial Identity · correlation 0.80
- Glial RNA Homeostasis · correlation 0.76
- Cytoskeletal Glial Homeostasis · correlation 0.76
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.