SPTBN1 — Spectrin beta, non-erythrocytic 1
SPTBN1 belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
SPTBN1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Integrin-Actin Adhesion migration & adhesion | APP, CHD3, CTNNA1, DAG1, DOCK6, FKBP9, FMNL3, ITGA9 +6 more | View in SCUBA |
| Enterocytes | Colonocyte terminal differentiation Epithelial development | CCDC186, CEACAM1, CMPK1, FHL2, GCNT3, HKDC1, IFNGR1, LRRFIP1 +2 more | View in SCUBA |
| Gamma-delta T cells | Nuclear Pore Organization Housekeeping | AIDA, DHX8, H4C6, LARP1, LBR, MPRIP, MTR, NNT +14 more | |
| Glial cells | Glial Synaptic Adhesion Neroprotection | AHNAK, ASPH, ATP1A2, CADM2, GATM, GRIK3, NRXN3, PCDH9 +1 more | View in SCUBA |
| Mucosal-associated invariant T cell | Cytoskeletal Migration migration & adhesion | AGTPBP1, AHNAK, ATP2B4, DIAPH1, FLNA, IQSEC1, ITCH, ITGA4 +8 more |
About the gene
| Chromosome | 2: 54456317-54671446 |
|---|---|
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Transporters |
| Molecular function | Actin capping, Actin-binding, Calmodulin-binding |
Function
Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane. Plays a critical role in central nervous system development and function
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.