Glial Homeostatic Identity
Gene co-expression module in Glial cells
| Category | Development |
|---|---|
| Genes | 9 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 8 of 9 genes have a known function matching the annotation |
Why this annotation
Hub genes include SEMA3C (semaphorin axon guidance/glial signaling), SORCS1 (neurotrophin receptor sorting, glial function), QKI (RNA-binding protein critical for glial identity and myelination-related RNA processing), GAS7 (glial differentiation/neurite outgrowth), ZBTB20 (transcription factor in glial/neuronal identity), VCL (vinculin, cytoskeletal adhesion), SIPA1L2 (signal-induced proliferation-associated, Rap GTPase signaling in neurons/glia), NUCKS1 (chromatin regulator), TMEM245 (transmembrane, expressed in glia). The module is core-coherent, uniformly expressed, and significantly downregulated during inflammation (UC and CD) with recovery at remission, consistent with a homeostatic glial identity program. The combination of QKI, GAS7, SEMA3C, and SORCS1 points strongly to a glial homeostatic/differentiation state program rather than any technical artifact.
Genes
GAS7, NUCKS1, QKI, SEMA3C, SIPA1L2, SORCS1, TMEM245, VCL, ZBTB20
Most correlated modules
- ECM Homeostatic Regulation · correlation 0.89
- Lysosomal Sphingolipid Metabolism · correlation 0.88
- Basement Membrane Adhesion · correlation 0.86
- Glial Synaptic Adhesion · correlation 0.85
- Glial RNA Homeostasis · correlation 0.83
- Enteric Glial Identity · correlation 0.83
- Glial Cytoskeletal Homeostasis · correlation 0.80
- Matricellular ECM Homeostasis · correlation 0.79
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.